发明名称 |
Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus |
摘要 |
A method heat treatment of cross-linked hemoglobin solutions including polymeric hemoglobin is disclosed. The method involves contacting the hemoglobin solution with a high temperature short time heat treatment apparatus. The high temperature short time process thermally denatures unmodified tetrameric hemoglobin (hemoglobin dimer form), protein impurities (e.g. immunoglobin-G, serum albumin), bacteria, and viruses so that renal injury, vascular detrimental effects and other toxicity reactions can be avoided. |
申请公布号 |
US8084581(B1) |
申请公布日期 |
2011.12.27 |
申请号 |
US201113217337 |
申请日期 |
2011.08.25 |
申请人 |
WONG BING LOU;KWOK SUI YI |
发明人 |
WONG BING LOU;KWOK SUI YI |
分类号 |
C07K14/00;A61K49/14;C07K14/805 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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