发明名称 |
CONJUGATE OF A POLYPEPTIDE AND SYNTHETIC SULFATED OLIGOSACCHARIDE, PHARMACEUTICAL COMPOSITION BASED THEREON |
摘要 |
The present invention relates to conjugates of a polypeptide and an oligosaccharide, wherein the polypeptide is conjugated to at least one oligosaccharide-spacer residue, the oligosaccharide being a synthetic sulfated oligosaccharide comprising 4-18 monosaccharide units and per se having affinity to antithrombin III and the spacer being a bond or an essentially pharmacologically inactive flexible linking residue, or a pharmaceutically acceptable salt thereof. The conjugates of the invention have improved pharmacokinetic properties when compared to the original polypeptides (i.e. the corresponding non-conjugated polypeptides per se). |
申请公布号 |
UA96916(C2) |
申请公布日期 |
2011.12.26 |
申请号 |
UA20070008223 |
申请日期 |
2006.01.31 |
申请人 |
N.V. ORGANON |
发明人 |
BOS EBO SYBREN;DE KORT MARTIN;SMIT MEERTINUS JAN;VAN BOECKEL CONSTANT ADRIAAN ANTON |
分类号 |
A61K47/48;A61K31/702;A61K38/16 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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