发明名称 |
PRODUCTION OF HETEROMULTIMERIC PROTEINS |
摘要 |
Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies. |
申请公布号 |
WO2011133886(A3) |
申请公布日期 |
2011.12.22 |
申请号 |
WO2011US33610 |
申请日期 |
2011.04.22 |
申请人 |
GENENTECH, INC.;F. HOFFMANN-LA ROCHE AG;SCHEER, JUSTIN;SPIESS, CHRISTOPH;YANSURA, DANIEL G. |
发明人 |
SCHEER, JUSTIN;SPIESS, CHRISTOPH;YANSURA, DANIEL G. |
分类号 |
A61K39/395;A61P35/00;C07K16/24;C07K16/28;C07K16/30;C07K16/46 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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