发明名称 |
CAGED CELL PENETRATING PEPTIDE-POLYMER CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS |
摘要 |
The caged cell-penetrating peptide (cCPP) conjugates of this invention are ideal for intracellular delivery of a broad variety of cargoes including various nanoparticulate pharmaceutical carriers (liposomes, micelles, microparticles, nanoparticles, polymer-conjugates). The conjugates comprise a detectable agent or a therapeutic agent, and the conjugates provide a novel strategy for site-specific delivery of the same to appropriate tissues in the subject. Versatile application of the conjugates in diagnostics and imaging is described. |
申请公布号 |
CA2800153(A1) |
申请公布日期 |
2011.12.08 |
申请号 |
CA20112800153 |
申请日期 |
2011.05.26 |
申请人 |
BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY |
发明人 |
DAVID, AYELET;ASHKENASY, GONEN;SHAMAY, YOSSI |
分类号 |
C07K17/02;A61K38/00;A61K41/00;A61K47/48;A61K49/00;C07K7/06 |
主分类号 |
C07K17/02 |
代理机构 |
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代理人 |
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主权项 |
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