发明名称 |
ONCOFETAL ANTIGEN SPECIFIC T-LYMPHOCYTE MEDIATED IMMUNE RESPONSE: MANIPULATION AND USES OF ONCOFETAL ANTIGEN SPECIFIC CD4, CD8 CYTOTOXIC AND SUPPRESSOR T CELLS AND INTERLEUKIN-10 |
摘要 |
The present invention provides a method of determining the success of a cancer therapy in an individual, comprising the step of measuring the frequency of occurrence of an oncofetal antigen-specific subclasses in the individual's peripheral blood. Also provided is a method of determining whether protective immunity against a tumor will develop in an individual, comprising the step of measuring the frequency of oncofetal antigen-specific T cells, tumor cells and macrophages at the site of the tumor which secrete IL-10. Additionally, a method of determining whether an individual having a tumor will go into remission or remain in remission, comprising the step of measuring the frequency of oncofetal antigen-specific Th1 cells, Tc cells and Ts cells, IL-10 and interferon-.gamma. secreting T cells in the peripheral blood.
|
申请公布号 |
CA2250164(C) |
申请公布日期 |
2011.12.06 |
申请号 |
CA19972250164 |
申请日期 |
1997.04.04 |
申请人 |
SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION |
发明人 |
COGGIN, JOSEPH H.;BARSOUM, ADEL L.;ROHRER, JAMES W. |
分类号 |
A61K39/00;A61K38/17;A61P35/00;C07K16/24;C12Q1/04;G01N33/574 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|