发明名称 |
Synthetic analogs of bacterial quorum sensors |
摘要 |
Bacterial quorum-sensing molecule analogs having the following structures: and methods of reducing bacterial pathogenicity, comprising providing a biological system comprising pathogenic bacteria which produce natural quorum-sensing molecule; providing a synthetic bacterial quorum-sensing molecule having the above structures and introducing the synthetic quorum-sensing molecule into the biological system comprising pathogenic bacteria. Further is provided a method of targeted delivery of an antibiotic, comprising providing a synthetic quorum-sensing molecule; chemically linking the synthetic quorum-sensing molecule to an antibiotic to produce a quorum-sensing molecule-antibiotic conjugate; and introducing the conjugate into a biological system comprising pathogenic bacteria susceptible to the antibiotic. |
申请公布号 |
US8071790(B2) |
申请公布日期 |
2011.12.06 |
申请号 |
US20090551994 |
申请日期 |
2009.09.01 |
申请人 |
IYER RASHI;GANGULY KUMKUM;SILKS LOUIS A.;LOS ALAMOS NATIONAL SECURITY, LLC |
发明人 |
IYER RASHI;GANGULY KUMKUM;SILKS LOUIS A. |
分类号 |
C07D333/36;C07D307/00 |
主分类号 |
C07D333/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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