RECOMBINANT HUMAN G-CSF DIMER AND USE THEREOF FOR THE TREATMENT OF NEUROLOGICAL DISEASES
摘要
Provided is a recombinant human G-CSF (rhG-CSF) dimer having prolonged serum half-life and increased biological activity of G-CSF, wherein the dimer is produced by two G-CSF-Fc complexes through the pairing of two Fc fragments via disulfide bonds, and the G-CSF-Fc complex comprises a G-CSF monomer, an Fc fragment of human IgG2, and a peptide connecting the G-CSF monomer and the Fc fragment. The rhG-CSF can be used for the treatment of neurological diseases.
申请公布号
WO2011147319(A1)
申请公布日期
2011.12.01
申请号
WO2011CN74678
申请日期
2011.05.25
申请人
GENERON (SHANGHAI) CORPORATION LTD.;YAN, XIAOQIANG;HUANG, ZHIHUA;YANG, HONGZHOU;SUN, BILL N.C.;HUANG, YULIANG
发明人
YAN, XIAOQIANG;HUANG, ZHIHUA;YANG, HONGZHOU;SUN, BILL N.C.;HUANG, YULIANG