发明名称 |
NUCLEOSIDE ARYL PHOSPHORAMIDATES AND THEIR USE AS ANTI-VIRAL AGENTS FOR THE TREATMENT OF HEPATITIS C VIRUS |
摘要 |
<p>Phosphoramidate derivatives of nucleoside compounds of formula I derived from bases such as adenine and guanine have enhanced therapeutic potency, in particular, enhanced potency with respect to the prophylaxis or treatment of a viral infection such as hepatitis C virus. The glycoside moiety of the nucleoside compound is suitably substituted at the ß-2' position with methyl and the phosphoramidate group, suitably comprises 1-naphthyl linked by -O- to the P atom.</p> |
申请公布号 |
WO2008062206(A8) |
申请公布日期 |
2011.11.10 |
申请号 |
WO2007GB04480 |
申请日期 |
2007.11.23 |
申请人 |
UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED;KATHOLIEKE UNIVERSITEIT LEUVEN;MCGUIGAN, CHRISTOPHER;NEYTS, JOHAN;PERRONE, PLINIO |
发明人 |
MCGUIGAN, CHRISTOPHER;NEYTS, JOHAN;PERRONE, PLINIO |
分类号 |
C07H19/20;A61K31/7076;A61K31/708;A61P31/14 |
主分类号 |
C07H19/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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