| 发明名称 |
METHOD OF PREPARATION AND USE PHARMACOLOGICALLY ACTIVE N-CARBAMOYLMETHYL-4(R)-PHENYL-2-PYRROLIDINONE |
| 摘要 |
The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R-Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia. |
| 申请公布号 |
UA96440(C2) |
申请公布日期 |
2011.11.10 |
| 申请号 |
UA20080012099 |
申请日期 |
2007.03.15 |
| 申请人 |
AKCIJU SABIEDRIBA "OLAINFARM" |
发明人 |
VEINBERG GRIGORY;VORONA MAKSIM;ZVEJNIECE LIGA;CHERNOBROVIJS ALEKSANDRS;KALVINSH, IVARS;KARINA LIGITA;DAMBROVA MAIJA |
| 分类号 |
C07D207/26;A61K31/4015;A61P21/02;A61P25/24 |
主分类号 |
C07D207/26 |
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