发明名称 METHODS FOR SYNTHESIZING KOTALANOL AND STEREOISOMERS AND ANALOGUES THEREOF, AND NOVEL COMPOUNDS PRODUCED THEREBY
摘要 Compounds having the general formula (I): wherein X is S, Se or NH, and stereoisomers thereof, and de-O-sulfonated analogues of all of the foregoing, but excluding naturally occurring kotalanol and de-O-sulfonated kotalanol, and methods for synthesizing same. The compounds are useful as glycosidase inhibitors, and may be used in the treatment of diabetes. The synthetic compounds may also be used as standards in the calibration or grading of natural or herbal remedies produced from natural sources of glycosidase inhibitors such as kotalanol.
申请公布号 US2011268822(A1) 申请公布日期 2011.11.03
申请号 US20090934898 申请日期 2009.03.25
申请人 SIMON FRASER UNIVERSITY 发明人 PINTO BRIAN MARIO;KUMARASAMY JAYAKANTHAN;NASI RAVINDRANATH;MOHAN SANKAR
分类号 A61K36/00;A61K31/33;A61K31/381;A61K31/40;A61P1/00;A61P3/10;C07D207/00;C07D333/46;C07D345/00;G01N27/447 主分类号 A61K36/00
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