QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY

摘要

The present invention relates to quinazoline containing zinc-binding moiety based derivatives that have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The said derivatives may further act as HDAC inhibitors.FIG. 1(a)