Streptomyces Avermitilis gene directing the ratio of B2:B1 avermectins
摘要
The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the ave C gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
申请公布号
EP2050815(B1)
申请公布日期
2011.10.26
申请号
EP20090150098
申请日期
2003.01.31
申请人
PFIZER PRODUCTS INC.
发明人
STUTZMAN-ENGWALL, KIM, JONELLE;GUSTAFSSON, CLAES, ERIC, DANIEL;KREBBER, ANKE;RAILLARD, SUN, AI;MINSHULL, JEREMY, STEPHEN;KIM, SERAN;CHEN, YAN