发明名称 |
A PROCESS FOR THE PREPARATION OF ISOSERINE DERIVATIVES |
摘要 |
This invention relates to a "one pot" process for the preparation of isoserine derivatives in high diastereoselective way. The process according to the invention includes the steps of reacting a protected glycidic acid with imines to yield isoserines protected both at the -OH and at the -COOH groups, deprotection of the obtained intermediates to isoserines or isoserine 1-4C- alkyl esters. Pure threo derivatives as the main isomer are obtained.
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申请公布号 |
CA2796240(A1) |
申请公布日期 |
2011.10.20 |
申请号 |
CA20112796240 |
申请日期 |
2011.04.13 |
申请人 |
INDENA S.P.A. |
发明人 |
FONTANA, GABRIELE;GELMI, MARIA LUISA;GASSA, FEDERICO |
分类号 |
C07C227/32 |
主分类号 |
C07C227/32 |
代理机构 |
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代理人 |
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地址 |
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