| 摘要 |
An apheresis/extra corporeal filtration device for selective capture of circulating tumour cells from a patient's blood comprises an inlet 4 to receive the patient's blood and a capture agent 1. The capture agent 1 binds to an extracellular portion of a protein expressed by the circulating tumour cell. A preferred protein is E-cadherin. The device also includes means for separating captured circulating tumour cells from the blood 8 and an outlet 9 for return of the remainder of the blood, depleted of circulating tumour cells, to the patient. The capture agent 1 may be immobilized on a solid support. The capture agent 1 may comprise a peptide comprising the amino acid sequence LFSHAVSSNG. |
