发明名称 |
BIOKINETICS OF FAST-CLEARING POLYPEPTIDES |
摘要 |
<p>Provided herein are methods of reducing liver uptake in vivo of a polypeptide that specifically binds to a target comprising: (a) providing a polypeptide that specifically binds to a target; and (b) substituting at least one basic or at least one neutral amino acid residue of the native polypeptide from step (a) with an acidic amino acid residue to produce a modified polypeptide, wherein the modified polypeptide demonstrates an isoelectric point at least 0.05-0.1 pH points less than the isoelectric point of the native polypeptide. Also provided are polypeptides made using the inventive methods as well as imaging techniques that employ the methods and agents.</p> |
申请公布号 |
EP2231706(B1) |
申请公布日期 |
2011.10.19 |
申请号 |
EP20080863248 |
申请日期 |
2008.12.17 |
申请人 |
GENERAL ELECTRIC COMPANY |
发明人 |
LENDEL, CHRISTOFER;GUNNERIUSSON, ELIN;LINDBORG, MALIN;LEE, BRIAN DUH-LAN;CASTLE, JASON WILLIAM;SYUD, FAISAL AHMED;MARINO, MICHAEL ERNEST |
分类号 |
C07K16/24;C07K16/00;C07K16/28;C07K16/32;C07K19/00;G01N33/00 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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