发明名称 SUBSTITUTED TETRAHYDROPYRAN SPIRO PYRROLIDINONE AND PIPERIDINONE, PREPARATION AND THERAPEUTIC USE THEREOF
摘要 <p>The present disclosure relates to a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I): wherein R1, R2, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefore are disclosed.</p>
申请公布号 EP2373659(A1) 申请公布日期 2011.10.12
申请号 EP20090775421 申请日期 2009.12.04
申请人 SANOFI 发明人 GAO, ZHONGLI;HARTUNG, RYAN;STEFANY, DAVID
分类号 C07D491/107;A61K31/407;A61K31/438;A61P25/00 主分类号 C07D491/107
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