Peptide compound with antimicrobial activity which is obtained from Bacillus clausii and is a lantibiotic and has lanthionine bridges and modified amino acids

摘要

Disclosed is a peptide compound wherein it: displays antimicrobial activity, it can be obtained from a culture of Bacillus clausii in a suitable medium up until sporulation, collection of the supernatant from the culture after centrifugation and filtration, and extraction of the fraction with antimicrobial activity, it is a lantibiotic and has lanthionine bridges and modified amino acids, it comprises the following amino acid sequence: Phe - Dhb - Ala - Val - Dha - Phe - Ala - Abu - Pro - Gly - Ala - Gly - Glu - Dhb - Gly - Ala - Phe - Asn - Ala - Phe - Ala in which Dhb represents a didehydroaminobutyrate; Dha represents a didehydroalanine; Abu represents an aminobutyrate. Also disclosed is the use of the said peptide compound for the preparation of a medicinal product intended for the treatment and/or prevention of intestinal disorders or of infectious diseases.