HEPATITIS C VIRUS INHIBITORS

摘要

Disclosed is a bis diazole imidazole substituted biphenyl compound of formula (I) where the substituents are as described in the description. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture of a medicament for treating HCV infection. Examples of compounds of formula (I) are: methyl ((1S)-1-(((2S)-2-(5-( 4'-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methyIbutanoyl)-2-pyrrolidinyI)-1H-imidazol-5-yl)-4-biphenyIyl)-1H -imidazol-2-yl)1-pyrrolidinyl)carbonyl)-2-methyIpropyI)carbamate; (1R,1'R)-2,2'-(4,4'-biphenyldiylbis(1H-imidazole-5,2-diyl(2S)-2,1-prrrolidinediyI))bis(N,N-dimethyl-2-oxo-1-phenylethanamine) and methyl ((1S)-2-((2S)-2-(5-(4'-(2-((2S)-1-((2R)-2-( diethylamino)-2-phenylacetyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)-1-methyl-2-oxoethyl)carbamate.