Insulin and IGF-1 receptor agonists and antagonists

摘要

Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites which are present on insulin and insulin-like growth factor receptors which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.
In one embodiment, the receptor-binding peptides comprise the core motive B6:
X 6 X 7 X 8 X 9 X 10 X 11 X 12 X 13 wherein X 6 and X 7 are aromatic, and X 10 and X 13 are hydrophobic residues.