| 摘要 |
<p>Described herein are engineered multilayered vascular tubes comprising an outer layer of differentiated adult fibroblasts, at least one inner layer of differentiated adult smooth muscle cells and differentiated adult endothelial cells, and having at least one of the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the engineered multilayered vascular tube is compliant; (c) the internal diameter of the engineered multilayered vascular tube is about 6 mm or smaller; (d) the length of the tube is about 1 cm to about 30 cm; and (e) the thickness of the engineered multilayered vascular tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is non-innervated and free of any pre-formed scaffold. Also described herein are methods of forming engineered multilayered vascular tubes. Further described herein are uses for engineered multilayered vascular tubes. Further described herein are methods for treating patients with damaged blood vessels, comprising providing an engineered multilayered vascular tube into a patient in need.</p> |
