发明名称 |
BORRELIA BURGDORFERI BACTERIN |
摘要 |
A bacterin including effective immunizing amounts of two non-crossprotective isolates of inactivated Borrelia burgdorferi, an adjuvant in an amount effective to enhance the immunogenicity of the inactivated Borrelia burgdorferi isolates and a suitable carrier is provided herein. The bacterin may also contain a third non-crossprotective isolate. A bacterin including effective immunizing amounts of an antigenic subunit derived from a first Borrelia burgdorferi isolate and a second, non-crossprotective Borrelia burgdorferi isolate, an adjuvant in an amount effective to enhance the immunogenicity of the antigenic subunits and a suitable carrier is also provided. The bacterin may also contain an effective immunizing amount of an antigenic subunit of a third Borrelia burgdorferi. Further provided is a bacterin which includes effective immunizing amounts of two non-crossprotective isolates of inactivated Borrelia burgdorferi and one or more antigenic subunits from the non-crossprotective isolates, an adjuvant in an amount effective to enhance the immunogenicity of the inactivated Borrelia burgdorferi and antigenic subunits and a suitable carrier. Methods of immunizing an animal against Borrelia burgdorferi infection which comprise administering to the animal a dose of a bacterin provided herein are also provided.
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申请公布号 |
CA2187535(C) |
申请公布日期 |
2011.09.13 |
申请号 |
CA19952187535 |
申请日期 |
1995.04.11 |
申请人 |
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发明人 |
KORSHUS, JON B.;RUNNELS, PAUL L.;SHARPEE, RICHARD L.;SCHELL, RONALD F.;CALLISTER, STEVEN M. |
分类号 |
A61K39/02;A61K39/00;A61P31/04;C07K14/20 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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