发明名称 |
Anti-Mpl antibodies |
摘要 |
Anti-human Mpl antibodies were isolated and purified. Anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were prepared using genetic engineering techniques and anti-human Mpl sc(Fv)2 was also humanized. The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.
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申请公布号 |
US8008073(B2) |
申请公布日期 |
2011.08.30 |
申请号 |
US20100874872 |
申请日期 |
2010.09.02 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
TSUNODA HIROYUKI;NAKANO KIYOTAKA;ORITA TETSURO;TSUCHIYA MASAYUKI;HIRATA YUICHI |
分类号 |
C12N5/07;C07H21/04;C07K16/28;C12N5/00;C12N15/00;C12P21/06 |
主分类号 |
C12N5/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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