发明名称 |
METHOD OF MULTIPLE SPIKING ISOTOPE DILUTION MASS SPECTROMETRY |
摘要 |
<p>A comprehensive approach for interpretation of the multiple spiking isotope dilution results is described herein. It has now been found that a method of multiple spiking isotope dilution analysis for mass spectrometry is possible using an approach that permits precise and simultaneous characterization of m substances from a sample even if species inter-conversion (degradation and formation) has occurred prior to separation. Advantageously, initial and final amounts of involved analytes, conversion extent, conversion degree and rate constants from the results of a single quantitation experiment may be obtained with the present method. In a particularly advantageous embodiment, uncertainty in the characterization of the substances may be estimated more accurately by also estimating increase in the uncertainty due to inter-conversion of the analytes.</p> |
申请公布号 |
EP2359125(A1) |
申请公布日期 |
2011.08.24 |
申请号 |
EP20090827085 |
申请日期 |
2009.11.18 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
OUERDANE, LAURENT;MEIJA, JURIS;MESTER, ZOLTAN |
分类号 |
H01J49/26;G01N27/00;H01J49/00 |
主分类号 |
H01J49/26 |
代理机构 |
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地址 |
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