2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY

摘要

The present invention provides a compound which has an effect of inhibiting amyloid-² production and is useful as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-² proteins. The present invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof:
wherein A is optionally substituted carbocyclic diyl or optionally substituted heterocyclic diyl; B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R 1 is a group such as optionally substituted lower alkyl; R 2 is a group such as hydrogen; and R 3a and R 3b are each independently a group such as hydrogen, provided that the following compound is excluded.