CHEMICALLY MODIFIED SIRNA AS LIPID-ABNORMAL DISEASE-TREATING MEDICINE

摘要

PROBLEM TO BE SOLVED: To provide a new modified siRNA molecule which is high in binding affinity with the target RNA of apolipoprotein B (ApoB) and has high stability in living bodies, and can exhibit an excellent RNA-interfering effect in the living bodies, and to provide a medicine composition containing the modified siRNA molecule as an active ingredient. SOLUTION: The modified siRNA decreases expression of ApoB gene, wherein (a) the modified siRNA molecule has an antisense chain RNA comprising a base sequence complementary to the sequence of a part of the ApoB gene and a modified sense chain RNA having a base sequence complementary to the antisense chain RNA, and (b) the modified sense chain RNA is a modified oligoribonucleotide comprising totally 19 to 23 ribonucleotides and ribonucleotide analogues. COPYRIGHT: (C)2011,JPO&INPIT