发明名称 |
[4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-[7-FLUORO-1-(2-METHOXY-ETHYL)-4-TRIFLUOROMETHOXY-1H-INDOL-3-YL]-METHANONE AS AN INHIBITOR OF MAST CELL TRYPTASE |
摘要 |
The present invention is directed to an indole benzylamine compound of formula I: useful as an inhibitor of tryptase. In addition, the present invention is directed to the use of the compound for treating a patient suffering from, or subject to, a physiological condition in need of amelioration by inhibition of tryptase, comprising administering to the patient of a therapeutically effective amount of the compound, and to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula I, and a pharmaceutically acceptable carrier.
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申请公布号 |
US2011201647(A1) |
申请公布日期 |
2011.08.18 |
申请号 |
US201113028745 |
申请日期 |
2011.02.16 |
申请人 |
CHOI-SLEDESKI YONG MI;CHOY NAKYEN;POLI GREGORY BERNARD;SHAY JR JOHN J;SHUM PATRICK WAI-KWOK;SLEDESKI ADAM W |
发明人 |
CHOI-SLEDESKI YONG MI;CHOY NAKYEN;POLI GREGORY BERNARD;SHAY, JR. JOHN J.;SHUM PATRICK WAI-KWOK;SLEDESKI ADAM W. |
分类号 |
A61K31/454;A61P1/00;A61P1/16;A61P11/00;A61P11/06;A61P17/00;A61P17/02;A61P27/02;A61P29/00;A61P31/12;A61P35/00;C07D401/06 |
主分类号 |
A61K31/454 |
代理机构 |
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主权项 |
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