EGF RECEPTOR MIMICKING PEPTIDES

摘要

Provided are peptides which can mimic the epidermal growth factor receptor (EGFR), e.g., by selectively binding TGF-a and/or EGF. In certain embodiments, the peptides are retro-inverted peptides. The peptides may be used as soluble decoys for TGF-a and/or EGF, and anti-cancer properties of peptides are demonstrated both in vitro and in vivo. The peptides may be administered alone or comprised in a fusion construct, imaging construct, and/or a therapeutic construct, e.g., for the treatment of a cancer.