SYNTHESIS OF DGJNAC FROM D-GLUCURONOLACTONE AND USE TO INHIBIT ALPHA-N-ACETYLGALACTOSAMINIDASES
摘要
<p>A convenient and scalable synthesis of DGJNAc ID from D-glucuronolactone in an overall yield of 20% is provided. DGJNAc is the first highly potent and specific competitive inhibitor of GalNAcases. DGJNAc ID is also a competitive inhibitor of -hexosaminidases. Synthesis and activity of L-DGJNAc IL is also shown. The use of DGJNAc as a potent and specific inhibitor of GalNAcases will allow useful investigation and treatment of a number of diseases, including Schindler Disease.</p>
申请公布号
WO2011095893(A1)
申请公布日期
2011.08.11
申请号
WO2011IB00380
申请日期
2011.01.28
申请人
UNIVERSITY OF OXFORD;FLEET, GEORGE, WILLIAM JOHN;BUTTERS, TERRY, DOUGLAS
发明人
FLEET, GEORGE, WILLIAM JOHN;BUTTERS, TERRY, DOUGLAS