发明名称 |
Nanoparticles For Drug Delivery To The Central Nervous System |
摘要 |
The present disclosure relates to compositions and methods for producing nanoparticles to provide relatively more rapid delivery of such particles across the blood-brain barrier. The nanoparticles may be formed from bis-quaternary pyridinium-aldoxime salts that may also be of a specific polymorphic structure and which may be formed in either hydrophobic or hydrophilic type liquid media. In addition, the nanoparticle for transport across the blood-brain barrier may comprise a polymeric resin encapsulating a bis-quaternary pyridinium-2-aldoxime salt of the formula: |
申请公布号 |
US2011195125(A1) |
申请公布日期 |
2011.08.11 |
申请号 |
US20100702095 |
申请日期 |
2010.02.08 |
申请人 |
SOUTHWEST RESEARCH INSTITUTE |
发明人 |
MCDONOUGH JOSEPH A.;DIXON HONG;CABELL LARRY A. |
分类号 |
A61K9/14;A61K31/444;A61P25/00;B32B5/00 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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