| 摘要 |
FIELD: medicine. ^ SUBSTANCE: what is described is new NRP1 antibodies including a variable region of a light chain containing CDRL1 which includes amino acid sequence RASQSISSYLA (SEQ ID NO:123), CDRL2 which includes amino acid sequence GASSRAS (SEQ ID NO:124) and CDRL3 which includes QQYMSVPIT (SEQ ID N0:125), and a variable region of a heavy chain containing CDRH1 which includes amino acid sequence GFSFSSEPIS (SEQ ID NO:126), CDRH2 which includes amino acid sequence SSITGKNGYTYYADSVKG (SEQ ID NO:127); and CDRH3 which includes amino acid sequence WGKKVYGMDV (SEQ ID NO:128). Also, application of the antibodies in research, diagnostic and therapeutic purposes is described. ^ EFFECT: invention allows extending the range of product for controlling the disorders associated with pathological angiogenesis. ^ 35 cl, 11 dwg, 5 tbl, 3 ex |
