发明名称 |
Oxyntomodulin analogues and their effects on feeding behaviour |
摘要 |
<p>Compounds of the invention are novel peptide analogues of oxyntomodulin (oxm) in which one or more amino acids of the oxm sequence have been changed. Changing amino acids 15-24 of oxm to either amino acids 968 - 977 of the ±-latrotoxin peptide (and variations thereof) or amino acids 15 - 24 of exendin-4 (and variations thereof), or combinations of sequences from these sources, and/or changing amino acids 27-33 of oxm to amino acids 27-33 of exendin-4, and/or the addition of amino acids to the C-terminus of the peptide, results in a series of analogues of oxm that demonstrate the oxm like activity of reducing food intake, and with certain embodiments a greater ability to decrease food intake.</p> |
申请公布号 |
EP2351776(A1) |
申请公布日期 |
2011.08.03 |
申请号 |
EP20100195787 |
申请日期 |
2006.06.13 |
申请人 |
IMPERIAL INNOVATIONS LIMITED |
发明人 |
BLOOM, STEPHEN ROBERT;GHATEI, MOHAMMAD ALI |
分类号 |
C07K14/605;A61K38/26;A61P3/04 |
主分类号 |
C07K14/605 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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