发明名称 |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates |
摘要 |
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
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申请公布号 |
US7989598(B2) |
申请公布日期 |
2011.08.02 |
申请号 |
US20070927251 |
申请日期 |
2007.10.29 |
申请人 |
IMMUNOGEN INC. |
发明人 |
STEEVES RITA M.;CHARI RAVI V. J.;BLATTLER WALTER A. |
分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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