摘要 |
<p>Disclosed are therapeutic methods using IL-6 antagonists such as an Ab 1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof Patients will preferably comprise those exhibiting (or atπsk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related proteιn(s), cachexia, fever, weakness and/or fatigue prior to treatment The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others</p> |
申请人 |
ALDER BIOPHARMACEUTICALS, INC. |
发明人 |
GARCIA - MARTINEZ, LEON;JENSEN, ANNE ELISABETH CARVALHO;OLSON, KATIE;DUTZAR, BEN;LATHAM, JOHN;KOVACEVICH, BRIAN;SMITH, JEFFREY T.L.;LITTON, MARK;SCHATZMAN, RANDALL |