发明名称 PHARMACEUTICAL FORMULATION 514
摘要 The present invention relates to a pharmaceutical formulation comprising the drug 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one in a solid dispersion with a matrix polymer that exhibits low hygroscopicity and high softening temperature, such as copovidone. The invention also relates to a daily pharmaceutical dose of the drug provided by such a formulation. In addition, the invention relates to the use of a matrix polymer that exhibits low hygroscopicity and high softening temperature in solid dispersion with 4-[3-(4-cyclopropanecarbonyl-piperazine-1 -carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one for increasing the bioavailability of the drug.
申请公布号 EP2346495(A1) 申请公布日期 2011.07.27
申请号 EP20090740728 申请日期 2009.10.05
申请人 ASTRAZENECA UK LIMITED 发明人 BECHTOLD, MICHAEL, KARL;PACKHAEUSER, CLAUDIA, BETTINA;CAHILL, JULIE, KAY;FASTNACHT, KATJA, MAREN;LIEPOLD, BERND, HARALD;LENNON, KIERAN, JAMES;STEITZ, BENEDIKT
分类号 A61K31/502;A61K47/32 主分类号 A61K31/502
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