发明名称 |
HIGHLY FUNCTIONAL ENZYME HAVING ALPHA-GALACTOSIDASE ACTIVITY |
摘要 |
The present invention provides, as an enzyme which can be used for enzyme replacement therapy for Fabry disease, a protein havingα-galactosidase activity, which shows no allergic adverse side effect, shows a high stability in blood, and can be easily incorporated into a cell of an affected organ. The protein of the present invention is a protein which has acquiredα-galactosidase activity by changing the structure of the active site of wild-type humanα-N-acetylgalactosaminidase.
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申请公布号 |
US2011171198(A1) |
申请公布日期 |
2011.07.14 |
申请号 |
US201113052632 |
申请日期 |
2011.03.21 |
申请人 |
TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH;ALTIF LABORATORIES |
发明人 |
SAKURABA HITOSHI;TAJIMA YOUICHI;ITO MAI;AIKAWA SEIICHI;AIKAWA FUMIKO |
分类号 |
C12N9/40;A61K38/47;A61P3/00;C12N5/10;C12N15/56;C12N15/85;C12P21/02 |
主分类号 |
C12N9/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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