| 发明名称 |
NOVEL INSULIN DERIVATIVES HAVING AN EXTREMELY DELAYED TIME-ACTION PROFILE |
| 摘要 |
The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof. |
| 申请公布号 |
US2011173722(A1) |
申请公布日期 |
2011.07.14 |
| 申请号 |
US20100820727 |
申请日期 |
2010.06.22 |
| 申请人 |
SANOFI-AVENTIS DEUTSCHLAND GMBH |
发明人 |
HABERMANN PAUL;SEIPKE GERHARD;KURRLE ROLAND;MULLER GUNTER;SOMMERFELD MARK;TENNAGELS NORBERT;TSCHANK GEORG;WERNER ULRICH |
| 分类号 |
A61K38/28;A01H5/00;A01H11/00;A61P3/10;A61P19/00;C07H21/04;C07K14/47;C07K14/62;C12N1/00;C12N15/63;C12P21/06 |
主分类号 |
A61K38/28 |
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