发明名称 |
METHOD OF MAKING BIOLOGICALLY ACTIVE ALPHA-BETA PEPTIDES |
摘要 |
Described is a method of fabricating biologically active, unnatural polypeptides. The method includes the steps of selecting a biologically active polypeptide or biologically active fragment thereof having an amino acid sequence comprising α-amino acid residues, and fabricating a synthetic polypeptide that has an amino acid sequence that corresponds to the sequence of the biologically active polypeptide, but wherein about 14% to about 50% of the α-amino acid residues found in the biologically active polypeptide or fragment of step (a) are replaced with &bgr;-amino acid residues, and the α-amino acid residues are distributed in a repeating pattern. |
申请公布号 |
KR20110071014(A) |
申请公布日期 |
2011.06.27 |
申请号 |
KR20117011077 |
申请日期 |
2009.10.14 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION |
发明人 |
HORNE WILLIAM S.;GELLMAN SAMUEL H.;JOHNSON LISA M. |
分类号 |
C07K14/00;A61K39/21;A61P31/14;C07K14/16 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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