| 摘要 |
<p>The present invention relates to a tumor marker or group of tumor markers associated with the progression of a cancer disease from a less progressed stage to a more progressed stage, wherein the expression of the tumor markers is modified when comparing the expression in the less progressed stage and in the more progressed stage. The present invention further relates to a composition for diagnosing, detecting, graduating, monitoring or prognosticating a cancer disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage comprising affinity ligands for the expression products of the tumor markers, to corresponding methods, and to the use of said tumor markers for detecting, diagnosing,graduating, monitoring or prognosticating a cancer disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage. The present invention further relates to a corresponding immunoassay, to a method of identifying an individual for eligibility for a cancer disease therapy, as well as to a pharmaceutical composition based on the inhibition of the expression of said tumor markers. The present invention further relates to a corresponding immunoassay for stratifying a patient or cohort of patients with a cancer disease associated with a progression from a less progressed cancer stage to a more progressed cancer stage to a therapeutic treatment for monitoring a therapeutic treatment of the stratified patient(s) during the progression from a less progressed cancer stage to a more progressed cancer stage.</p> |
