IMMUNOMODULATING POLYPEPTIDES DERIVED FROM IL-2 AND USE THEREOF IN CANCER AND CHRONIC INFECTIONS

摘要

The invention relates in general to polypeptides having a primary sequence that is highly homologous with the sequence of human interleukin-2 (IL-2) with some punctual mutations in the sequence of native IL-2. The polypeptides of the invention have an immunomodulating effect on the immune system, which is selective/preferential in relation to regulatory T cells. The invention also relates to specific polypeptides of which the amino acid sequence is disclosed in the present invention. The invention further relates to pharmaceutical compositions containing the disclosed polypeptides as an active principle. Finally, the invention relates to the therapeutic use of said polypeptides and pharmaceutical compositions, given the immune-system-modulating effect thereof on pathologies such as cancer and chronic infectious diseases.