发明名称 |
LATERAL FLOW DEVICE FOR DIAGNOSING MICROBIAL INFECTIONS |
摘要 |
Fungal infections are difficult to diagnose. The most common filamentous fungal infection, aspergillosis, carries with it a high mortality. Culture of the organism is difficult and obtaining samples, e.g., though a lung biopsy, sometimes causes morbidity. Biomarkers that indicate 'early' infection in it development are sought after. One such biomarker is detection of galactomannan (GM), a polysaccharide that is attached to hyphal cell walls and secreted during growth of the organism. Galactomannan is excreted in urine. Disclosed herein is a lateral flow assay comprising monoclonal antibodies that recognize specific residues of Aspergillus fumigates for detecting GM in urine samples to provide a point-of-care detection device to allow for frequent screening and early diagnosis in patients at high risk for infection. |
申请公布号 |
WO2011063395(A2) |
申请公布日期 |
2011.05.26 |
申请号 |
WO2010US57819 |
申请日期 |
2010.11.23 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;MARR, KIERAN, A.;YESHIVA UNIVERSITY;FELDMESSER, MARTA;STAAB, JANET, F. |
发明人 |
MARR, KIERAN, A.;FELDMESSER, MARTA;STAAB, JANET, F. |
分类号 |
G01N33/569;C12R1/46;C12R1/66;G01N33/538 |
主分类号 |
G01N33/569 |
代理机构 |
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代理人 |
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地址 |
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