发明名称 |
PHARMACEUTICAL COMPOSITIONS OF ENTACAPONE, LEVODOPA AND CARBIDOPA WITH IMPROVED BIOAVAILABILITY |
摘要 |
The present invention relates to single oral dose pharmaceutical compositions comprising a combination of entacapone, levodopa and carbidopa, or salts thereof along with one or more sugar alcohols, wherein the entacapone is co-micronized with one or more sugar alcohols. The composition of the invention exhibits bioequivalence to commercially available entacapone, levodopa and carbidopa combination formulation marketed under the trade name Stalevo200®. The invention also relates to processes for making such compositions. |
申请公布号 |
EP2252284(B1) |
申请公布日期 |
2011.05.25 |
申请号 |
EP20090709056 |
申请日期 |
2009.02.06 |
申请人 |
WOCKHARDT RESEARCH CENTRE |
发明人 |
TALWAR, MUNISH;KAPOOR, RITESH;MASHALKAR, MANOJ;JAIN, GIRISH KUMAR |
分类号 |
A61K31/275;A61K9/14;A61K9/16;A61K9/26;A61K31/195;A61K31/198;A61K47/26 |
主分类号 |
A61K31/275 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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