发明名称 |
HIV VACCINE BASED ON TARGETING MAXIMIZED GAG AND NEF TO DENDRITIC CELLS. |
摘要 |
<p>The present invention includes compositions and methods for making and using a vaccine that includes a DC-specific antibody or fragment thereof to which an engineered Gag antigen is attached to form an antibody-antigen complex, wherein the Gag antigen is less susceptible to proteolytic degradation by eliminating one or more proteolytic sites or a DC-specific antibody or fragment thereof to which an engineered Nef antigen is attached to form an antibody-antigen complex, wherein the Nef antigen comprises one or more codon usage optimization that increase antibody-antigen complex secretion, or both, wherein the vaccine is able to elicit an HIV-specific T cell immune response to Gag p17, Gag p24, Nef and/or Cy clin D1.</p> |
申请公布号 |
MX2011000507(A) |
申请公布日期 |
2011.05.24 |
申请号 |
MX20110000507 |
申请日期 |
2009.07.16 |
申请人 |
BAYLOR RESEARCH INSTITUTE |
发明人 |
BANCHEREAU, JACQUES, F.;ZURAWSKI, GERARD;FLAMAR, ANNE-IAURE;COBB, AMANDA;MEAD, HOLLY;MONTES, MONICA |
分类号 |
A61K39/12;A61K39/395 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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