PEPTIDE WHICH PASSES THROUGH BLOOD-BRAIN BARRIER AND TARGETS APOPTOSIS OF NEURODEGENERATIVE BRAIN DISEASE SITE AND USES THEREOF

摘要

The invention relates to a peptide which passes through a blood-brain barrier and targets apoptosis of degenerative brain disease sites and uses thereof, and more specifically, to a composition for delivering drugs to brain tissues comprising a peptide having an amino acid sequence as represented in SEQ ID NO:1 as an active ingredient, a composition for detecting apoptotic cells of neurodegenerative brain disease sites, and a composition for imaging the sites of neurodegenerative brain disease and said peptide and a composition combined therewith for preventing, treating or therapeutically diagnosing neurodegenerative brain diseases. The peptide having the amino acid sequence as represented by SEQ ID NO:1 of the present invention can pass through the blood-brain barrier and specifically bind to apoptotic cells in tissues of neurodegenerative brain diseases. Therefore the peptide of the present invention can be used for a variety of purposes such as detection of apoptosis in neurodegenerative brain diseases, and further, detection and imaging diagnosis of apoptotic cells (particularly, apoptotic nerve cells) in tissues of neurodegenerative brain diseases, delivery of target drugs, diagnosis for treatment, and the like.