发明名称 |
CYTOMEGALOVIRUS DISINTEGRIN-LIKE PEPTIDES |
摘要 |
The present invention relates to methods and compositions for inhibiting the entry of viruses, such as herpesviruses into a host cell. A conserved viral integrin-binding gB disintegrin-like domain has been identified that engages integrins and facilitates viral internalization into the host cell. Therefore, methods and compositions, such as antiviral agents encompassing the conserved gB disintegrin-like domain and antibodies thereto are described. These active agents interfere with the interaction between virions and cellular integrins, thereby inhibiting viral infection of a host cell.
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申请公布号 |
US2011117109(A1) |
申请公布日期 |
2011.05.19 |
申请号 |
US20090369650 |
申请日期 |
2009.02.11 |
申请人 |
COMPTON TERESA;FEIRE ADAM LLOYD |
发明人 |
COMPTON TERESA;FEIRE ADAM LLOYD |
分类号 |
A61K39/42;A61K38/17;A61K39/245;A61K39/395;A61P31/12;A61P31/22;C07K14/045;C07K14/705;C07K16/08;C07K16/28;C12N5/071 |
主分类号 |
A61K39/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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