| 摘要 |
PROBLEM TO BE SOLVED: To provide an industrial method of producing sugar fluorinated at the anomeric position. SOLUTION: A hexose pyranosyl fluoride protector, a pentose pyranosyl fluoride protector, a hexose franosyl fluoride protector or a pentose franosyl fluoride protector can be produced by reacting a hexose pyranose protector, a pentose pyranose protector, a hexose franose protector or a pentose furanose protector respectively with sulfuryl fluoride (SO<SB>2</SB>F<SB>2</SB>) in the presence of an organic alkali. The reaction may be carried out by further allowing the presence of [a salt or a complex comprised of an organic base and hydrogen fluoride] in the reaction system according to the need therefor. The industrial method of producing sugar fluorinated at the anomeric position can employ a low-cost fluorinating agent and a simple purification operation in its post-treatment process, has no restriction with respect to the material for constructing its reaction apparatus, and can be applied to a raw material substrate comprising a hydroxyl protected group at the 2-position that can be expected to exhibit the neighboring group participation. COPYRIGHT: (C)2011,JPO&INPIT
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