发明名称 |
A METHOD FOR THE IDENTIFICATION OF DRUG TARGETS |
摘要 |
The present invention relates to the field of drug development. More specifically the invention provides a method for the identification of drug targets. The method can also be used for analysis of proteomes. The method utilizes in essence a combination of two chromatographic separations of the same type, separated by a step in which the population of the drug-bound targets is altered specifically on the drug in such a way that the chromatographic behaviour of the altered drug-bound targets in the second chromatographic separation differs from the chromatographic behaviour of its unaltered version. The different chromatographic behaviour of the altered drug-bound targets is used for the isolation and subsequent identification of the targets.
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申请公布号 |
CA2498352(C) |
申请公布日期 |
2011.05.10 |
申请号 |
CA20032498352 |
申请日期 |
2003.09.11 |
申请人 |
VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE VZW;UNIVERSITEIT GENT |
发明人 |
VANDEKERCKHOVE, JOEL;GEVAERT, KRIS |
分类号 |
G01N27/62;G01N33/68;C07K7/06;C12Q1/37;C40B30/04;G01N30/06;G01N30/46;G01N30/72;G01N30/88 |
主分类号 |
G01N27/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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