| 发明名称 |
Immunostimulatory nucleic acid molecules |
| 摘要 |
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.
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| 申请公布号 |
US7935675(B1) |
申请公布日期 |
2011.05.03 |
| 申请号 |
US19990337584 |
申请日期 |
1999.06.21 |
| 申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
KRIEG ARTHUR M.;KLINE JOEL N. |
| 分类号 |
A61K31/70;C12N15/09;A01N43/04;A61K9/127;A61K31/00;A61K31/175;A61K31/335;A61K31/47;A61K31/4706;A61K31/7088;A61K39/00;A61K39/38;A61K39/39;A61K39/395;A61K45/00;A61K47/48;A61K48/00;A61P1/00;A61P1/02;A61P1/04;A61P11/06;A61P17/06;A61P19/02;A61P31/04;A61P31/12;A61P33/00;A61P35/00;A61P37/02;A61P37/04;A61P37/06;A61P37/08;A61P43/00;C07H21/00;C07H21/02;C07H21/04;C07K14/52;C12N15/11;C12Q1/68 |
主分类号 |
A61K31/70 |
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