发明名称 |
POLYMERIC SYSTEMS FOR THE DELIVERY OF ANTICANCER AGENTS |
摘要 |
The present invention relates to compositions for the treatment of cancerous tissues in warm-blooded animals containing one or two anticancer agents attached to polymeric carriers having monomer units derived from one or more of N-(2-carboxypropyl)methacrylamide (2-CPMA), N-(3-carboxypropyl)methacrylamide (3-CPMA), N-(2-aminopropyl)methacrylamide (2-APMA) and/or N-(3-aminopropyl)methacrylamide (3-APMA) are also included. Anticancer agents in compositions can be attached to said polymeric carrier by side-chains which can be susceptible to hydrolysis by lysosomal enzymes intracellularly. Compositions can also include a targeting ligand attached to the polymeric carrier, optionally through a second linker. |
申请公布号 |
WO2011047051(A2) |
申请公布日期 |
2011.04.21 |
申请号 |
WO2010US52510 |
申请日期 |
2010.10.13 |
申请人 |
REXAHN PHARMACEUTICALS, INC.;LEE, YOUNG BOK;KIM, DEOG JOONG;AHN, CHANG HO |
发明人 |
LEE, YOUNG BOK;KIM, DEOG JOONG;AHN, CHANG HO |
分类号 |
A61K47/32;A61K38/05;A61K38/08;A61K38/43;A61K47/30;A61P35/00 |
主分类号 |
A61K47/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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