发明名称 |
METHODE FÜR DIE AUSARBEITUNG VON CD10-AKTIVIERTEN PRODRUG-VERBINDUNGEN |
摘要 |
The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing a prodrug are also disclosed. |
申请公布号 |
AT504315(T) |
申请公布日期 |
2011.04.15 |
申请号 |
AT20020746852T |
申请日期 |
2002.06.11 |
申请人 |
MEDAREX, INC. |
发明人 |
BEBBINGTON, CHRISTOPHER;NIEDER, MATTHEW;CARDARELLI, PINA;GANGWAR, SANJEEV;PICKFORD, LESLEY;PAN, CHIN |
分类号 |
A61K47/48;A61K31/704;A61K45/00;A61K49/00;A61P35/00;A61P35/02;A61P35/04;A61P43/00;C07K5/06;C07K5/083;C12Q1/37;G01N33/68 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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