| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a method of producing N-substituted bis[dialkoxyphosphoryl]acetamidines, which can be used to produce biologically active compounds of formula: where R1 = i-C3H7, C4H9; R2=CH3, C3H5; X=-N(C2H5)2, -N(C3H7)2, -N(C4H9)2; -N(CH2CH2)2O. The disclosed method involves reaction of C-phosphorylated acetamidines of formula where R1=i-C3H7, C4H9; X=-N(C2H5)2, -N(C3H7)2, -N(C4H9)2; -N(CH2CH2)2O, with sodium with subsequent phosphorylation of the obtained derivative with dimethylchlorophosphate or diethylchlorophosphate in dioxane in molar ratio C-phosphorylated acetamidine: sodium: dialkylchlorophosphate equal to 1:1:1:1.05 and temperature 20-50C. ^ EFFECT: efficient novel method of obtaining the said compound. ^ 1 cl, 5 ex |
